Some favourites from Frankfurt
Maincafé, Schaumainkai, Frankfurt, Deutschland – great for sitting by the river and drinking Apple Wine
Schwedler See Bar, Frankfurt – out in east Frankfurt there is a outdoor swimming club which opens up at night for live music and chilled atmosphere bar
Hoppers, Schneckenhofstraße, Frankfurt – suburban cocktails
Cafe Karin / Walden- Great brunch spots
Maintower Restaurant & Bar, Neue Mainzer Straße, Frankfurt am Main – great view and good for high-end food
Flemings Terrace Bar, Frankfurt – cool lifts and nice view for good cocktaisl
22nd Lounge & Bar Eurotheum Residence, Neue Mainzer Straße, Frankfurt – piano bar (not hipster really!)
Vai Vai, Grüneburgweg, Frankfurt – a favourite modern Italian restaurant
Shirn Kunsthalle – great modern art gallery
Day trips:
Heidelberg - wander the old town, the Neckar River and go up to the castle
Rheingau wine region - take a car out to the numerous wineries within an hour of Frankfurt
Lorelei - http://en.wikipedia.org/wiki/Lorelei